Two miles of new fencing will create a 'buffer zone' to protect the park's 600 deer herd, rare sheep and farm animals, from visitors.
But Home Farm and the Knutsford entrances to the estate will remain closed as part of the foot-and-mouth restrictions.
Visitors will be admitted at the Rostherne entrance only where there will be strict disinfection procedures.
The National Trust-owned property closed in February as a precaution against the outbreak.
Since then it has missed out on about £17,000 a week with an expected £40,000 over Easter.
Cheshire's foot-and-mouth task force this week backed the decision following a major risk assessment under new MAFF and National Trust guidelines.
"This decision will give a tremendous boost to tourism both regionally and locally," said task force leader Derek Bateman.
"Not only that, but the estate is also an important educational and cultural centre for the county as a whole and creates at least 50 seasonal jobs each year."
Tatton's magnificent neo classical mansion - packed with art treasures - the original Tudor Old Hall, shops and restaurant, will all open.
Visitors will also get their first glimpse of the newly-restored Japanese gardens first laid out by Japanese craftsmen in 1910 for the 3rd Lord Egerton.
The gardens will be officially reopened on May 23.
Tatton's reopening will allow the estate to stage the Royal Horticultural Society Flower Show on July 18-22 and also the equally spectacular Halle fireworks concerts on July 28.
"We are delighted to be able to welcome the public back to Tatton," said Cty Clr Larry Toale.
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