Rishi Sunak has refused to apologise and said it is "sad and wrong" to link his transgender joke at Prime Minister's Questions to the murdered teenager's case.

Mr Sunak was criticised for the "degrading" and "dehumanising" remark made in the Commons.

Mr Sunak had accused Sir Keir Starmer of having difficulty in "defining a woman" during an attack on Labour Party U-turns.

Esther Ghey, the mother of Brianna, who was transgender, was visiting Parliament when Mr Sunak aimed the jibe at Sir Keir.

His comment prompted fierce criticism from across the political spectrum, with Sir Keir telling Mr Sunak: "Of all the weeks to say that, when Brianna's mother is in this chamber. Shame."

But on Thursday the Prime Minister claimed it was "the worst of politics" to link his comments to Brianna's case.

Warrington Guardian: Prime Minister Rishi Sunak is visiting Cornwall (PA)

On a visit to Cornwall he told reporters: "Like everyone, I was completely shocked by Brianna's case. To have your child taken from you in such awful circumstances is almost impossible to come to terms with, and for Brianna's mum to talk with such empathy and compassion about that, I thought, was inspiring, and it showed the very best of humanity.

"I've nothing but the most heartfelt sympathy for her entire family and friends.

"But to use that tragedy to detract from the very separate and clear point I was making about Keir Starmer's proven track record of multiple U-turns on major policies, because he doesn't have a plan, I think is both sad and wrong, and it demonstrates the worst of politics."

Asked to respond to Mr Spooner's demand for an apology, Mr Sunak insisted his comments had been "absolutely legitimate".

"If you look at what I said, I was very clear, talking about Keir Starmer's proven track record of U-turns on major policies because he doesn't have a plan."

Warrington Guardian: Brianna Ghey's mum has thanked the people of Warrington for their support following the death of

Ms Ghey, on the Facebook page of the Peace & Mind UK campaign she set up in her daughter's memory, later wrote: "I don't wish to comment on reports of wording or comments recently made. My focus is on creating a positive change and a lasting legacy for Brianna.

"Through Peace & Mind, we want to improve lives by empowering people, giving them the tools they need to build mental resilience, empathy and self-compassion through mindfulness. In developing these skills, I hope that we can create a more understanding, peaceful and stronger society for everyone."

Cabinet minister Penny Mordaunt suggested Mr Sunak had "reflected on things" after his comments.

The Commons Leader said: "Whatever the rough and tumble of this place, whatever the pressures and mistakes that are made in the heat of political combat, we owe it to the people who sent us here to strive every day to make them proud of us and this place."

She added: "That is not just about (Brianna's parents) that he should reflect on, but I am sure he is also reflecting about people who are trans, or who have trans loved ones and family, some of whom sit on these green benches.

"I hope the leader of the Opposition will also reflect on his actions too."

Tory former business minister Paul Scully told the BBC's Politics Live: "If it was me, I would probably pick up the phone to Brianna's father, frankly."

Earlier, policing minister Chris Philp said Mr Sunak is "very keen" to meet Brianna's family and it is understood Number 10 has reached out to arrange a meeting.

Brianna's mother had been in Westminster during PMQs with her local MP in Warrington, Charlotte Nichols, as she campaigns for mindfulness lessons to be taught in schools following the killing of her daughter.

More than £67,000 has now been raised in the campaign with the Warrington Guardian.

Brianna was stabbed to death by teenagers Scarlett Jenkinson and Eddie Ratcliffe in a Cheshire park last February.

During their sentencing earlier this month, the judge said the "exceptionally brutal" murder had elements of both sadism on the part of Jenkinson and transphobic hate on the part of Ratcliffe.

Downing Street rejected the suggestion that Mr Sunak repeatedly used transgender people as a punchline or a joke, but made clear his views on gender identity have not changed.

"He's said that it shouldn't be controversial to be clear on what the definition of a woman is. That's not least because of the fundamental facts of biological sex being critically important in areas such as healthcare and other services," his official spokesman said.